ALP-based HPP calculator

Diagnosing HPP

When interpretating laboratory test results for the diagnosis of hypophosphatasia (HPP), it is important to determine the lower limits of alkaline phosphatase (ALP) using age- and sex-specific reference intervals (RIs).1

You can calculate ALP RIs for children and adolescents using the tool below, which includes five major analytical platforms - Abbott, Beckman, Ortho, Roche and Siemens, developed by the Canadian Laboratory Initiative in Pediatric Reference Intervals (CALIPER).1

 

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ALP, alkaline phosphatase; HPP, hypophosphatasia; RI, reference interval.

Reference:
  1. Adeli K, et al. The Canadian laboratory initiative on pediatric reference intervals: A CALIPER white paper. Crit Rev Clin Lab Sci. 2017;54(6):358–413.
  2. ARUP. Alkaline phosphatase isozymes, Serum or plasma. Available at: https://ltd.aruplab.com/Tests/Pub/0021020. Last accessed: February 2024.
  3. Colantonio DA, et al. Closing the gaps in pediatric laboratory reference intervals: a CALIPER database of 40 biochemical markers in a healthy and multiethnic population of children. Clin Chem. 2012;58:854–868.
  4. Adeli K. Biochemical Marker Reference Values across Pediatric, Adult, and Geriatric Ages: Establishment of Robust Pediatric and Adult Reference Intervals on the Basis of the Canadian Health Measures Survey. Clin Chem. 2015;61(8):1049–1062.
  5. Schumann G. IFCC primary reference procedures for the measurement of catalytic activity concentrations of enzymes at 37 °C. Part 9: Reference procedure for the measurement of catalytic concentration of alkaline phosphatase. Clin Chem Lab Med. 2011;49(9):1439–1446.
  6. Quest Diagnostics. Alkaline phosphatase. Available at: https://testdirectory.questdiagnostics.com/test/test-detail/234/alkaline-phosphatase?cc=MASTER. Last accessed February 2024.
  7. Labcorp. Alkaline phosphatase. Available at: https://www.labcorp.com/tests/001107/alkaline-phosphatase. Last accessed February 2024.
  8. Bishop N. Transformative therapy in hypophosphatasia. Arch Dis Child. 2016;101(6):514–515.
  9. Rockman-Greenberg C. Hypophosphatasia. Pediatr Endocrinol Rev. 2013;10(Suppl 2):380–388.
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