Peer-developed support in a new era of breast cancer pathology


With recent clinical advancements there is a need for consistency in HER2 IHC assessment across the full spectrum of expression. HER2Know provides a collection of clinical cases and whole slide images (WSIs), tools to assess your HER2 IHC scoring consistency, and a range of educational resources to help you refine your approach to HER2 IHC scoring.

DOCUMENTARY

The significance of HER2

Dr. Hope S. Rugo, medical oncologist, and Dr. Marilyn M. Bui, pathologist, discuss the advances of HER2 in this short documentary. View the trailer (on the right) or the full film, below.

    

IHC Atlas

70+ hand-selected clinical cases, with WSI viewing, representing a range of staining patterns and intensities. 

View clinical cases

Supporting Resources

An expanding resource center with clinical support tools, including microscopy aids, reference guides, virtual microscopy sessions, and more.

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IHC Knowledge Check

Scoring practice with a collection of clinical cases, provided with consensus scores and interpretations by the Pathology Faculty.

Test your knowledge

    

PEER-LED EDUCATION

Pathology Faculty

This peer-led educational platform is developed in collaboration with leading pathologists who have special interest in breast HER2 IHC assessment. All consensus scored cases presented on this platform have been peer-reviewed by at least six pathologists.

Members of the Breast Pathology Faculty have been contracted as paid advisors through Daiichi Sankyo and AstraZeneca, and have received compensation for their time. 

Marilyn Bui MD, PhD

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Michael Feldman MD, PhD

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David Hicks MD

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Shabnam Jaffer MD

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Thaer Khoury MD

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Savitri Krishnamurthy MD

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Gary Tozbikian MD

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Shi Wei MD, PhD

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Hannah Wen MD, PhD

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PATHOLOGY FACULTY

By pathologists for pathologists

    

HER2, human epidermal growth factor receptor 2; IHC, immunohistochemistry; ISH, in situ hybridization; RPCCC, Roswell Park Comprehensive Cancer Center; WSI, whole slide image.